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Multi-influential interactions alters behaviour and cognition through six main biological cascades in Down syndrome mouse models

Archive ouverte | Duchon, Arnaud | CCSD

Down syndrome (DS) is the most common genetic form of intellectual disability caused by the presence of an additional copy of human chromosome 21. To provide novel insights into genotype–phenotype correlations, we screened the in ...

Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome

Archive ouverte | Gundersen, Brigitta, B | CCSD

A microdeletion on human chromosome 16p11.2 is one of the most common copy number variants associated with autism spectrum disorder and other neurodevelopmental disabilities. Arbaclofen, a GABA(B) receptor agonist, is a component ...

Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models

Archive ouverte | Martin Lorenzo, Sandra | CCSD

International audience. Background Gene copy number variants have an important role in the appearance of neurodevelopmental disorders. Particularly, the deletion of the 16p11.2 locus is associated with autism spectr...

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