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Nucleus-invadopodia duo during cancer invasion 1

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Ferrari, Robin | Infante, Elvira | Chavrier, Philippe

Edité par CCSD ; Elsevier -

International audience. Matrix proteolysis mediated by MT1-MMP facilitates the invasive migration of tumor cells in dense tissues, which otherwise get trapped in the matrix because of limited nuclear deformability. A digest-on-demand response has been identified, which requires nucleus-microtubule linkage through the LINC complex and triggers MT1-15

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