Tubulin Posttranslational Modifications and Emerging Links to Human Disease

Archive ouverte

Magiera, Maria, M. | Singh, Puja | Gadadhar, Sudarshan | Janke, Carsten

Edité par CCSD ; Elsevier -

International audience. Tubulin posttranslational modifications are currently emerging as important regulators of the microtubule cytoskeleton and thus have a strong potential to be implicated in a number of disorders. Here, we review the latest advances in understanding the physiological roles of tubulin modifications and their links to a variety of pathologies.

Suggestions

Du même auteur

Molecular interactions between tubulin tails and glutamylases reveal determinants of glutamylation patterns

Archive ouverte | Natarajan, Kathiresan | CCSD

International audience. Posttranslational modifications of tubulin currently emerge as key regulators of microtubule functions. Polyglutamylation generates a variety of modification patterns that are essential for c...

Mechanisms and functions of the tubulin code 1 2 3 4

Archive ouverte | Janke, Carsten | CCSD

International audience

Tubulin polyglutamylation, a regulator of microtubule functions, can cause neurodegeneration

Archive ouverte | Bodakuntla, Satish | CCSD

International audience. Neurodegenerative diseases lead to a progressive demise of neuronal functions that ultimately results in neuronal death. Besides a large variety of molecular pathways that have been linked to...

Chargement des enrichissements...