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Manganese-induced turnover of TMEM165

Archive ouverte | Potelle, Sven | CCSD

International audience. TMEM165 deficiencies lead to one of the congenital disorders of glycosylation (CDG), a group of inherited diseases where the glycosylation process is altered. We recently demonstrated that th...

Involvement of thapsigargin– and cyclopiazonic acid–sensitive pumps in the rescue of TMEM165-associated glycosylation defects by Mn 2+

Archive ouverte | Houdou, Marine | CCSD

International audience. Congenital disorders of glycosylation are severe inherited diseases in which aberrant protein glycosylation is a hallmark. Transmembrane protein 165 (TMEM165) is a novel Golgi transmembrane p...

Dissection of TMEM165 function in Golgi glycosylation and its Mn2+ sensitivity

Archive ouverte | Lebredonchel, Elodie | CCSD

International audience. Since 2012, the interest for TMEM165 increased due to its implication in a rare genetic human disease named TMEM165-CDG (Congenital Disorder(s) of Glycosylation). TMEM165 is a Golgi localized...

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