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Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice

Archive ouverte | Yvert, Gaël | CCSD

Among the eight progressive neurodegenerative diseases caused by polyglutamine expansions, spinocerebellar ataxia type 7 (SCA7) is the only one to display degeneration in both brain and retina. We show here that mice overexpressin...

Polyglutamine expansion causes neurodegeneration by altering the neuronal differentiation program

Archive ouverte | Abou-Sleymane, Gretta | CCSD

International audience. Huntington's disease (HD) and spinocerebellar ataxia type 7 (SCA7) belong to a group of inherited neurodegenerative diseases caused by polyglutamine (polyQ) expansion in corresponding protein...

Hsp70 and Hsp40 Chaperones Do Not Modulate Retinal Phenotype in SCA7 Mice

Archive ouverte | Helmlinger, Dominique | CCSD

International audience. Nine neurodegenerative diseases, including spinocer-ebellar ataxia type 7 (SCA7), are caused by the expansion of polyglutamine stretches in the respective disease causing proteins. A hallmark...

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