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Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis

Archive ouverte | Mouhand, Assia | CCSD

International audience. During HIV-1 assembly and budding, Gag protein, in particular the C-terminal domain containing the nucleocapsid domain (NCd), p1 and p6, is the site of numerous interactions with viral and ce...

Investigation of the Low-Populated Excited States of the HIV-1 Nucleocapsid Domain

Archive ouverte | Mouhand, Assia | CCSD

International audience. The nucleocapsid domain (NCd), located at the C-terminus of the HIV-1 Gag protein, is involved in numerous stages of the replication cycle, such as the packaging of the viral genome and rever...

Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States

Archive ouverte | Mouhand, Assia | CCSD

International audience. HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured ...

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