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Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase

Archive ouverte | Ezpeleta, Juliette | CCSD

International audience. Although cellular prion protein PrPC is well known for its implication in Transmissible Spongiform Encephalopathies, its functions remain elusive. Combining in vitro and in vivo approaches, w...

Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation

Archive ouverte | Alleaume-Butaux, Aurélie | CCSD

International audience. In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, ...

Cerebellar compartmentation of prion pathogenesis

Archive ouverte | Ragagnin, Audrey | CCSD

International audience. In prion diseases, the brain lesion profile is influenced by the prion “strain” properties, the invasion route to the brain, and still unknown host cell‐specific parameters. To gain insight i...

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