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Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

Archive ouverte | Neumann, Beate | CCSD

International audience

Wapl is an essential regulator of chromatin structure and chromosome segregation

Archive ouverte | Tedeschi, Antonio | CCSD

International audience. Mammalian genomes contain several billion base pairs of DNA that are packaged in chromatin fibres. At selected gene loci, cohesin complexes have been proposed to arrange these fibres into hig...

Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression

Archive ouverte | Wirth, Karin | CCSD

International audience. Separase is a protease whose liberation from its inhibitory chaperone Securin triggers sister chromatid disjunction at anaphase onset in yeast by cleaving cohesin's kleisin subunit. We have c...

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