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The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice

Archive ouverte | Papanikos, Frantzeskos | CCSD

International audience. Meiosis is a critical phase in the life cycle of sexually reproducing organisms. Chromosome numbers are halved during meiosis, which requires meiosis-specific modification of chromosome behav...

Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice

Archive ouverte | Dereli, Ihsan | CCSD

International audience. In most taxa, halving of chromosome numbers during meiosis requires that homologous chromosomes (homologues) pair and form crossovers. Crossovers emerge from the recombination-mediated repair...

PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment

Archive ouverte | Imai, Yukiko | CCSD

International audience. Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9-binding sites. The molecular steps occurring from PRD...

Chargement des enrichissements...