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qDSB-Seq is a general method for genome-wide quantification of DNA double-strand breaks using sequencing

Archive ouverte | Zhu, Yingjie | CCSD

International audience. DNA double-strand breaks (DSBs) are among the most lethal types of DNA damage and frequently cause genome instability. Sequencing-based methods for mapping DSBs have been developed but they a...

i-BLESS is an ultra-sensitive method for detection of DNA double-strand breaks

Archive ouverte | Biernacka, Anna | CCSD

International audience. Maintenance of genome stability is a key issue for cell fate that could be compromised by chromosome deletions and translocations caused by DNA double-strand breaks (DSBs). Thus development o...

Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

Archive ouverte | Promonet, Alexy | CCSD

International audience. R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops in the human genome, here, we map RNA:DNA hybrids, replication stress markers and DNA double...

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