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Lack of correlation between the activity of the mesolimbic dopaminergic system and the rewarding properties of pregabalin in mouse

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Coutens, Basile | Mouledous, L. | Stella, Manta | Rampon, Claire | Lapeyre-Mestre, Maryse | Roussin, Anne | Guiard, Bruno | Jouanjus, Emilie

Edité par CCSD ; Springer Verlag -

International audience. Pregabalin is a psychoactive drug indicated in the treatment of epilepsy, neuropathic pain, and generalized anxiety disorders. Pregabalin acts on different neurotransmission systems by inactivating the alpha2-delta subunit of voltage-gated calcium channels. In light of this pharmacological property, the hypothesis has been raised that pregabalin may regulate the mesolimbic dopamine pathway and thereby display a potential for misuse or abuse as recently observed in humans. Although some preclinical data support this possibility, the rewarding properties of gabapentinoid are still a matter for debate.

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