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Cytomegalovirus Infection of the Rat Developing Brain In Utero Prominently Targets Immune Cells and Promotes Early Microglial Activation

Archive ouverte | Cloarec, Robin | CCSD

International audience. Background Congenital cytomegalovirus infections are a leading cause of neurodevelopmental disorders in human and represent a major health care and socio-economical burden. In contrast with t...

In Utero Administration of Drugs Targeting Microglia Improves the Neurodevelopmental Outcome Following Cytomegalovirus Infection of the Rat Fetal Brain

Archive ouverte | Cloarec, Robin | CCSD

International audience. Congenital cytomegalovirus (CMV) infections represent one leading cause of neurodevelopmental disorders. Recently, we reported on a rat model of CMV infection of the developing brain in utero...

Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero

Archive ouverte | Salmi, Manal | CCSD

International audience. Altered development of the human cerebral cortex can cause severe malformations with often intractable focal epileptic seizures and may participate in common pathologies, notably epilepsy. Th...

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