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Neoantigen quality predicts immunoediting in survivors of pancreatic cancer

Archive ouverte | Łuksza, Marta | CCSD

International audience. Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more immunogenic cancer cells to cause less immunogenic clones to dominate a population. Although proven i...

Generative models of T-cell receptor sequences

Archive ouverte | Isacchini, Giulio | CCSD

International audience. T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to recognize infections and malignancies. M...

Population variability in the generation and thymic selection of T-cell repertoires

Archive ouverte | Sethna, Zachary | CCSD

International audience. The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selection based on ...

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