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Bromodomain and extraterminal (BET) protein inhibition of IgG/IgE production in murine B cells is counter-balanced by a strong Th2 bias

Archive ouverte | Dalloul, Zeinab | CCSD

International audience. OBJECTIVES: Inhibitors of bromodomain and extra terminal domain (BET) proteins are a new and growing class of anti-cancer drugs, which decrease oncogene expression by targeting superenhancers...

Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B- cells from inflamed human lymphoid tissues

Archive ouverte | Dalloul, Iman | CCSD

International audience

Attempts to evaluate locus suicide recombination and its potential role in B cell negative selection in the mouse

Archive ouverte | Denis-Lagache, Nicolas | CCSD

International audience. Introduction - In mature B cells, activation-induced deaminase reshapes Ig genes through somatic hypermutation and class switch recombination of the Ig heavy chain () locus under control of i...

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