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Triggering Cu-coordination change in Cu( ii )-Ala-His-His by external ligands

Archive ouverte | Gonzalez, Paulina | CCSD

International audience. Cu(II) forms well-known and stable complexes with peptides having histidine at position 2 (Xxx-His) or 3 (Xxx-Zzz-His). Their properties differ considerably due to the histidine positioning. ...

Revisiting the pro-oxidant activity of copper: interplay of ascorbate, cysteine, and glutathione

Archive ouverte | Falcone, Enrico | CCSD

Copper (Cu) is essential for most organisms, but it can be poisonous in excess, through mechanisms such as protein aggregation, trans-metallation, and oxidative stress. The latter could implicate the formation of potentially harmf...

Human serum albumin as a copper source for anticancer thiosemicarbazones

Archive ouverte | Schaier, Martin | CCSD

Thiosemicarbazones (TSCs) are a class of biologically active compounds with promising anticancer activity. Their typical mechanism, especially of the clinically far developed representative Triapine, is chelation of iron (Fe), wit...

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