The circular RNome of primary breast cancer

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Smid, Marcel | Wilting, Saskia, M | Uhr, Katharina | Rodríguez-González, F. Germán | de Weerd, Vanja | Prager-van Der Smissen, Wendy J.C. | van Der Vlugt-Daane, Michelle | van Galen, Anne | Nik-Zainal, Serena | Butler, Adam, P | Martin, Sancha | Davies, Helen, R | Staaf, Johan | van de Vijver, Marc, J | Richardson, Andrea, L | Macgrogan, Gaëten | Salgado, Roberto | van den Eynden, Gert G.G.M. | Purdie, Colin, A | Thompson, Alastair, M | Caldas, Carlos | Span, Paul, N | Sweep, Fred C.G.J. | Simpson, Peter, T | Lakhani, Sunil, R | van Laere, Steven | Desmedt, Christine | Paradiso, Angelo | Eyfjord, Jorunn | Broeks, Annegien | Vincent-Salomon, Anne | Futreal, Andrew, P | Knappskog, Stian | King, Tari | Viari, Alain | Børresen-Dale, Anne-Lise | Stunnenberg, Hendrik, G | Stratton, Mike | Foekens, John, A | Sieuwerts, Anieta, M | Martens, John W.M.

Edité par CCSD ; Cold Spring Harbor Laboratory Press -

International audience. Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs that does not rely on unmapped reads or known splice junctions. We identified 95,843 circRNAs, of which 20,441 were found recurrently. Of the circRNAs that match exon boundaries of the same gene, 668 showed a poor or even negative (R < 0.2) correlation with the expression level of the linear gene. In silico analysis showed only a minority (8.5%) of circRNAs could be explained by Corresponding author: m.smid@erasmusmc.nl Article published online before print. Article, supplemental material, and publication date are at

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