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The CCM1–CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity

Archive ouverte | Lisowska, Justyna | CCSD

International audience. Endothelial integrity relies on a mechanical crosstalk between intercellular and cell-matrix interactions. This crosstalk is compromised in hemorrhagic vascular lesions of patients carrying l...

Impaired retinoic acid signaling in cerebral cavernous malformations

Archive ouverte | Grdseloff, Nastasja | CCSD

International audience. The capillary-venous pathology cerebral cavernous malormation (CCM) is caused by loss o CCM1/Krev interaction trapped protein 1 (KRIT1), CCM2/MGC4607, or CCM3/PDCD10 in some endothelial cel...

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

Archive ouverte | Otten, Cécile | CCSD

International audience. Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system causing strokes and seizures which currently can only be treated through neurosurgery. The disease a...

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