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Effects of siRNA-squalene nanoparticles on RET/PTCs junction oncogenes in papillary thyroid carcinoma : from molecular and cellular studies to preclinical investigations. Effets des nanoparticules de siRNA-Squalène sur les oncogènes de jonction RET/PTCs dans le carcinome papillaire de la thyroïde : études moléculaires, cellulaires et investigations précliniques

Archive ouverte | Ali, Hafiz Muhammad | CCSD

Papillary thyroid carcinoma (PTC) is the most common of thyroid cancers. PTC is characterized by chromosomal rearrangements affecting chromosome 10 and leading to RET/PTC junction oncogenes. The most frequent ones are RET/PTC1 and...

Significance and applications of nanoparticles in siRNA delivery for cancer therapy

Archive ouverte | Ali, Hafiz Muhammad | CCSD

International audience. RNAi is a powerful gene silencing process that holds great promise in cancer therapy by the use of siRNA. The aim of this review is to give an outline on different approaches to deliver siRNA...

Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer

Archive ouverte | Urbinati, Giorgia | CCSD

International audience. TMPRSS2-ERG junction oncogene is present in more than 50% of patients with prostate cancer and its expression is frequently associated with poor prognosis. Our aim is to achieve gene knockdow...

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