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Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

Archive ouverte | Gibbings, Derrick | CCSD

International audience. MicroRNAs (miRNAs) form a class of short RNAs (similar to 21 nucleotides) that post-transcriptionally regulate partially complementary messenger RNAs. Each miRNA may target tens to hundreds o...

Ago Hook and RNA Helicase Motifs Underpin Dual Roles for SDE3 in Antiviral Defense and Silencing of Nonconserved Intergenic Regions

Archive ouverte | Garcia, Damien | CCSD

International audience. In Arabidopsis thaliana, the putative RNA-helicase SDE3 assists posttranscriptional-gene-silencing (PTGS) amplification by RNA-dependent-RNA-polymerase-6 (RDR6). SDE3 homologs in Drosophila, ...

Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein.

Archive ouverte | Azevedo, Jacinthe | CCSD

International audience. In plants and invertebrates, viral-derived siRNAs processed by the RNaseIII Dicer guide Argonaute (AGO) proteins as part of antiviral RNA-induced silencing complexes (RISC). As a counterdefen...

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