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Functional analysis of the relationship between Vpx and the restriction factor SAMHD1.

Archive ouverte | Berger, Gregory | CCSD

International audience. SAMHD1 is a newly identified restriction factor that targets lentiviruses in myeloid cells and is countered by the SIV(SM)/HIV-2 Vpx protein. By analyzing a large panel of Vpx mutants, we ide...

IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

Archive ouverte | Tartour, Kevin | CCSD

International audience. BACKGROUND: Interferon induced transmembrane proteins 1, 2 and 3 (IFITMs) belong to a family of highly related antiviral factors that have been shown to interfere with a large spectrum of vir...

Evidence for a different susceptibility of primate lentiviruses to type I interferons.

Archive ouverte | Cordeil, Stéphanie | CCSD

International audience. Type I interferons induce a complex transcriptional program that leads to a generalized antiviral response against a large panel of viruses, including human immunodeficiency virus type 1 (HIV...

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