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Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging

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Thakare, Vivek | Tran, Vu-Long | Natuzzi, Marco | Thomas, Eloise | Moreau, Mathieu | Romieu, Anthony | Collin, Bertrand | Courteau, Alan | Vrigneaud, Jean-Marc | Louis, Cédric | Roux, Stéphane, G. | Boschetti, Frédéric | Tillement, Olivier | Lux, François | Denat, Franck

Edité par CCSD ; Royal Society of Chemistry -

International audience. A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with 64Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.

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