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Amphiphilic polymers based on polyoxazoline as relevant nanovectors for photodynamic therapy

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Oudin, Amandine | Chauvin, Julie | Gibot, Laure | Rols, Marie-Pierre | Balor, Stephanie | Goudounèche, Dominique | Payre, Bruno | Lonetti, Barbara | Vicendo, Patricia | Mingotaud, Anne-Françoise | Lapinte, Vincent

Edité par CCSD ; Royal Society of Chemistry -

International audience. An amphiphilic polymer (CmPOX) based on poly(2-methyl-2-oxazoline) linked to a hydrophobic part composed of an aliphatic chain ended by a photo-active coumarin group has been synthesized. It exhibits the ability of forming small polymeric self-assemblies, typically of ca. 10 nm in size which were characterized by TEM, cryo-TEM and DLS. The nanocarriers were further formulated to yield photo-crosslinked systems by dimerization of coumarin units of a coumarinfunctionalized poly(methyl methacrylate) (CmPMMA) and CmPOX. The formed vectors were used to encapsulate Pheophorbide a, a known photosensitizer for PhotoDynamic Therapy. Cytotoxicity as well as photooxicity experiments led in vitro on human tumor cells revealed the great potential of these nanovectors for photodynamic therapy.

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