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Desmin aggrephagy in rat and human ischemic heart failure through PKCζ and GSK3β as upstream signaling pathways

Archive ouverte | Bouvet, Marion | CCSD

International audience. Post-translational modifications of cardiac proteins could participate to left contractile dysfunction resulting in heart failure. Using a rat model of ischemic heart failure, we showed an ac...

Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure

Archive ouverte | Dubois-Deruy, Emilie | CCSD

International audience. Aims: Previous studies have reported that decreased serine 208 phosphorylation of troponin T (TnTpSer208) is associated with ischaemic heart failure (HF), but the molecular mechanisms and fun...

Interplay between phosphorylation and O-GlcNAcylation of sarcomeric proteins in ischemic heart failure Running title: Interplay between phosphorylation and O-GlcNacylation of sarcomeric proteins

Archive ouverte | Mercier, Thomas | CCSD

International audience. Post-translational modifications (PTMs) of sarcomeric proteins could participate to left ventricular (LV) remodeling and contractile dysfunction leading in advanced heart failure (HF) with al...

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