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The trimeric coiled‐coil HSBP 1 protein promotes WASH complex assembly at centrosomes

Archive ouverte | Visweshwaran, Sai | CCSD

International audience. The Arp2/3 complex generates branched actin networks that exert pushing forces onto different cellular membranes. WASH complexes activate Arp2/3 complexes at the surface of endosomes and ther...

CYFIP2 containing WAVE complexes inhibit cell migration

Archive ouverte | Polesskaya, Anna | CCSD

Branched actin networks polymerized by the Arp2/3 complex are critical for cell migration. The WAVE complex is the major Arp2/3 activator at the leading edge of migrating cells. However, multiple distinct WAVE complexes can be ass...

Restrained activation of CYFIP2-containing WAVE complexes controls membrane protrusions and cell migration

Archive ouverte | Polesskaya, Anna | CCSD

Abstract Branched actin networks polymerized by the Arp2/3 complex are critical for cell migration. The WAVE complex is the machinery that activates Arp2/3 in a RAC1-dependent manner at the leading edge of migrating cells. Multipl...

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