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MDM-2 protein is expressed in different layers of normal human skin

Archive ouverte | Dazard, J. E. | CCSD

International audience. MDM-2 is one of the target genes of the p53 tumor suppressor protein. Its best characterized function is found in the inhibition of p53's ability to modulate transcription. Deregulated expres...

The proto-oncogene c-fos increases the sensitivity of keratinocytes to apoptosis

Archive ouverte | Mils, V. | CCSD

International audience. In human skin, most studies have suggested a role of c-fos or c-fos related genes in keratinocyte differentiation. The aim of our work was to more directly address this question by transfecti...

Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size

Archive ouverte | Dazard, J. E. | CCSD

International audience. p53 transcription factor is mutated in most skin cell carcinomas and in more than 50% of all human malignancies. One of its transcriptional targets is MDM2, which in turn down-regulates p53. ...

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