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Management of human thymomas : development of thymic epithelial cell cultures derived from tumors for the understanding of tumoral cells dysregulation. Prise en charge des thymomes chez l'homme : développement de cultures de cellules épithéliales dérivées de tumeurs pour la compréhension des dérégulations de la cellule tumorale

Archive ouverte | Maury, Jean-Michel | CCSD

Human thymic epithelial tumors (TETs) are rare (250 – 300 cases/ year in France). We distinguish thymomas (A, AB and B subtypes) with indolent evolution (5 years actuarial survival in early stages >95%) and more aggressive thymic ...

Optimal management of thymic malignancies: current perspectives

Archive ouverte | Drevet, Gabrielle | CCSD

International audience. Thymic epithelial tumors (TETs) belong to orphan oncology. The incidence of TETs is about 1.3-3.2 cases per million worldwide. Following pathology, evolution and prognosis are variable. The W...

Activation of the mTOR/Akt pathway in thymic epithelial cells derived from thymomas

Archive ouverte | Maury, Jean-Michel | CCSD

International audience. The pathogenesis of thymic epithelial tumors remains poorly elucidated. The PIK3/Akt/mTOR pathway plays a key role in various cancers; interestingly, several phase I/II studies have reported ...

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