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Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice

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Demeilliers, Christine | Maisonneuve, Caroline | Grodet, Alain | Mansouri, Abdellah | Nguyen, Richard | Tinel, Marina | Lettéron, Philippe | Degott, Claude | Feldmann, Gerard | Pessayre, Dominique | Fromenty, Bernard

Edité par CCSD ; Elsevier -

International audience. A single dose of alcohol causes transient hepatic mitochondrial DNA (mtDNA) depletion in mice followed by increased mtDNA synthesis and an overshoot of mtDNA levels. We determined the effect of repeated alcohol binges on hepatic mtDNA in mice.

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