Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties

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Dobre, D. | Borer, J. S. | Fox, K. | Swedberg, K. | Adams, K. F. | Cleland, J. G. | Cohen-Solal, A. | Gheorghiade, M. | Gueyffier, François | O'Connor, C. M. | Fiuzat, M. | Patak, A. | Pina, I. L. | Rosano, G. | Sabbah, H. N. | Tavazzi, L. | Zannad, F.

Edité par CCSD ; European Society of Cardiology (Wiley) -

International audience. Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbidities, and disease phenotype. Beneficial and harmful interactions may also exist. The aim of this paper is to summarize the current body of knowledge regarding the relevance of heart rate as a prognostic factor (risk marker) and particularly as a therapeutic target (risk factor) in patients with chronic heart failure, with a special focus on ivabradine, a novel agent that is currently the only available purely bradycardic agent.

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