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Gluconoylated and Glycosylated Polylysines As Vectors for Gene Transfer into Cystic Fibrosis Airway Epithelial Cells

Archive ouverte | Kollen, Wouter | CCSD

International audience. To provide an alternative to viral vectors for the transfer of genes into airway epithelial cells in cystic fibrosis (CF), a novel set of substituted polylysines were employed. Polylysine was...

Membrane lectins on human monocytes. Maturation-dependent modulation of 6-phosphomannose and mannose receptors.

Archive ouverte | Roche, Annie-Claude | CCSD

International audience. Freshly isolated human monocytes, which do not contain cell-surface mannose-specific receptors, bind mannose 6-phosphate and actively endocytose mannose 6-phosphate-bearing neoglycoproteins (...

Cytosolic and Nuclear Delivery of Oligonucleotides Mediated by an Amphiphilic Anionic Peptide

Archive ouverte | Pichon, Chantal | CCSD

International audience. Antisense oligonucleotides (ODN) were easily introduced into the cytosol of mammalian cells on permeabilization of the plasma membrane by an amphiphilic anionic peptide. The E5CA peptide (GLF...

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