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Prominent role for T cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection.

Archive ouverte | Allie, Nasiema | CCSD

International audience. Tumour Necrosis Factor (TNF) is critical for host control of M. tuberculosis, but the relative contribution of TNF from innate and adaptive immune responses during tuberculosis infection is u...

Limited role for lymphotoxin α in the host immune response to Mycobacterium tuberculosis.

Archive ouverte | Allie, Nasiema | CCSD

International audience. The contribution of lymphotoxin (LT)α in the host immune response to virulent Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guérin infections was investigated. Despite ...

Reactivation of tuberculosis by tumor necrosis factor neutralization.

Archive ouverte | Jacobs, Muazzam | CCSD

Tumor necrosis factor (TNF) is required in the control of infection with Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. TNF is essential and non-redundant for forming microbiocidal granulomas, and cannot be...

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