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Diverging roads to the heart

Archive ouverte | Sperling, Silke | CCSD

International audience. The vertebrate heart tube forms from epithelial progenitor cells in the early embryo and subsequently elongates by progressive addition of second heart field (SHF) progenitor cells from adjac...

T-box genes and retinoic acid signaling regulate the segregation of arterial and venous pole progenitor cells in the murine second heart field

Archive ouverte | de Bono, Christopher | CCSD

International audience. The arterial and venous poles of the mammalian heart are hotspots of congenital heart defects (CHD) such as those observed in 22q11.2 deletion (or DiGeorge) and Holt-Oram syndromes. These reg...

Epithelial tension in the second heart field promotes mouse heart tube elongation

Archive ouverte | Francou, Alexandre | CCSD

International audience. Extension of the vertebrate heart tube is driven by progressive addition of second heart field (SHF) progenitor cells to the poles of the heart. Defects in this process cause a spectrum of co...

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