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A Functional and Regulatory Network Associated with PIP Expression in Human Breast Cancer

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Debily, Marie-Anne | Marhomy, Sandrine El | Boulanger, Virginie | Eveno, Eric | Mariage-Samson, Régine | Camarca, Alessandra | Auffray, Charles | Piatier-Tonneau, Dominique | Imbeaud, Sandrine

Edité par CCSD ; Public Library of Science -

International audience. The PIP (prolactin-inducible protein) gene has been shown to be expressed in breast cancers, with contradictory results concerning its implication. As both the physiological role and the molecular pathways in which PIP is involved are poorly understood, we conducted combined gene expression profiling and network analysis studies on selected breast cancer cell lines presenting distinct PIP expression levels and hormonal receptor status, to explore the functional and regulatory network of PIP co-modulated genes.

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