Afficher la couverture 'Claramines: A New Class Of Broad-Spectrum Antimicrobial Agents With Bimodal Activity | Blanchet, Marine' en grand format
/5

0 avis

Claramines: A New Class Of Broad-Spectrum Antimicrobial Agents With Bimodal Activity

Archive ouverte

Blanchet, Marine | Borselli, Diane | Rodallec, Anne | Peiretti, Franck | Vidal, Nicolas | Bolla, Jean-Michel, M | Di Giorgio, Carole | Morrison, Kelly, R | Wuest, William, M | Brunel, Jean Michel

Edité par CCSD ; Wiley-VCH Verlag -

International audience. The emergence of multidrug resistant bacteria/pathogens has highlighted the need for the development of new antibiotics. In this manuscript, we report herein our results dealing with the broad spectrum of antibacterial activity against both sensitive and resistant Gram-negative and Gram-positive bacterial strains of an easily prepared water soluble polyaminosterol compound namely claramine A1. We will also demonstrate its peculiar mechanism of action (different from all the well-known classes of antibiotics) towards Gram-negative and Gram-positive bacteria. Finally, due to its low cytotoxicity, this class of molecules could constitute an effective response to combat the emergence of multidrug resistant bacteria and nosocomial diseases.

Suggestions

Du même auteur

Polyamine derivatives: a revival of an old neglected scaffold to fight resistant Gram-negative bacteria?

Archive ouverte | Blanchet, Marine | CCSD

International audience. Emergence of multidrug resistant pathogens was responsible for microbial infections and inefficacy of numerous antimicrobial therapies has induced a need for the research of new classes of an...

Motuporamine Derivatives as Antimicrobial Agents and Antibiotic Enhancers against Resistant Gram-Negative Bacteria

Archive ouverte | Borselli, Diane | CCSD

International audience

Polyamino-Isoprenic Derivatives Block Intrinsic Resistance of P. aeruginosa to Doxycycline and Chloramphenicol In Vitro

Archive ouverte | Borselli, Diane | CCSD

International audience. Multidrug resistant bacteria have been a worldwide concern for decades. Though new molecules that effectively target Gram-positive bacteria are currently appearing on the market, a gap remain...

Chargement des enrichissements...