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Trimethylarsonium-Based Cationic Phospholipids for Gene Delivery

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Berchel, Mathieu | Le Corre, Stéphanie | Le Gall, Tony | Couthon, Hélène | Haelters, Jean-Pierre | Midoux, Patrick | Montier, Tristan | Lehn, Pierre | Jaffres, Paul-Alain

Edité par CCSD ; Taylor & Francis -

International audience. Lipophosphoramide-based cationic lipids are a class of synthetic vectors used for gene delivery that can be produced in multigram scale. The use of trimethylarsonium moiety as a cationic polar head was beneficial to produce efficient gene delivery vectors for in vivo applications. Moreover, this type of cationic lipid can also exhibit some bactericidal effects.

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