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Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test

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Dortet, Laurent | Bonnin, Rémy | Pennisi, Ivana | Gauthier, Laura | Jousset, Agnès | Dabos, Laura | Furniss, R Christopher D | Mavridou, Despoina | Bogaerts, Pierre | Glupczynski, Youri | Potron, Anaïs | Plesiat, Patrick | Beyrouthy, Racha | Robin, Frédéric | Bonnet, Richard | Naas, Thierry | Filloux, Alain | Larrouy-Maumus, Gerald | Gauthier, Lauraine

Edité par CCSD ; Oxford University Press (OUP) -

International audience. Polymyxins are currently considered a last-resort treatment for infections caused by MDR Gram-negative bacteria. Recently, the emergence of carbapenemase-producing Enterobacteriaceae has accelerated the use of polymyxins in the clinic, resulting in an increase in polymyxin-resistant bacteria. Polymyxin resistance arises through modification of lipid A, such as the addition of phosphoethanolamine (pETN). The underlying mechanisms involve numerous chromosome-encoded genes or, more worryingly, a plasmid-encoded pETN transferase named MCR. Currently, detection of polymyxin resistance is difficult and time consuming.

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