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Dynamics of Epstein-Barr viral load after hematopoietic stem cell transplantation and effect of preemptive rituximab therapy

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Raberahona, Mihaja | Wackenheim, Chloe | Germi, Raphaële | Carré, Martin | Bulabois, Claude-Eric | Thiébaut, Anne, C.M. | Lupo, Julien | Semenova, Touyana | Cahn, Jean-Yves | Morand, Patrice | Epaulard, Olivier

Edité par CCSD ; Wiley -

International audience. Epstein-Barr virus (EBV) displays oncogenic properties, particularly in the immunocompromised host. Notably, hematopoietic stem cell transplantation (HSCT) recipients with a detectable blood EBV viral load (BEBVL) are considered at higher risk of post-transplant lymphoproliferative diseases (PTLD). Therefore, BEBVL is monitored after HSCT, and preemptive rituximab may be used in patients with high values. However, little is known about post-HSCT BEBVL dynamics, and the threshold that should lead to anti-CD20 therapy is poorly defined.

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