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Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation

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Elantak, Latifa | Espeli, Marion | Boned, Annie | Bornet, Olivier | Bonzi, Jeremy | Gauthier, Laurent | Feracci, Mikael | Roche, Philippe | Guerlesquin, Francoise | Schiff, Claudine

Edité par CCSD ; American Society for Biochemistry and Molecular Biology -

International audience. Background: Galectin-1 (GAL1) is a ligand for the pre-BCR which is involved in the proliferation and differentiation of normal pre-BII cells. Results: GAL1-dependent pre-BCR clustering is driven mainly by hydrophobic contacts. Conclusion: Constitutive and ligand-induced pre-BCR activation can occur in a complementary manner. Significance: This is the first molecular snapshot of a pre-BCR/ligand interaction that helps pre-BCR clustering and activation.

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