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The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs

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Lambolez, Florence | Arcangeli, Marie-Laure | Joret, Anne-Marie | Pasqualetto, Valerie | Cordier, Corinne | Di Santo, James P | Rocha, Benedita | Ezine, Sophie

Edité par CCSD ; Nature Publishing Group -

International audience. Thymic export of cells is believed to be restricted to mature T cells. Here we show that the thymus also exports fully committed T cell precursors that colonize primary lymphoid organs. These precursor cells exited the thymus before T cell receptor rearrangements and colonized lymphoid organs such as the thymus and the gut. Migration of the thymic T cell–committed precursors led to permanent colonization of the gut precursor compartment, improved the capacity of gut precursors to further differentiate into T cells and was sufficient for the generation of 'euthymic like' CD8αα+ intraepithelial lymphocytes. These data demonstrate a new function for the thymus in peripheral seeding with T cell precursors that become long lived after thymus export.

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