Functional aspects of the X-ray structure of mitochondrial creatine kinase: A molecular physiology approach

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Schlattner, Uwe | Forstner, Michael | Eder, Michael | Stachowiak, Olaf | Fritz-Wolf, Karin | Wallimann, Theo

Edité par CCSD ; Springer Verlag -

International audience. Mitochondrial creatine kinase (Mi-CK) is a central enzyme in energy metabolism of tissues with high and fluctuating energy requirements. In this review, recent progress in the functional and structural characterization of Mi-CK is summarized with special emphasis on the solved X-ray structure of chicken Mib-CK octamer (Fritz-Wolf et al., Nature 381, 341-345, 1996). The new results are discussed in a historical context and related to the characteristics of CK isoforms as known from a large number of biophysical and biochemical studies. Finally, two hypothetical functional aspects of the Mi-CK structure are proposed: (i) putative membrane binding motifs at the top and bottom faces of the octamer and (ii) a possible functional role of the central 20 Å channel.

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