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Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Archive ouverte | Uvarov, Pavel | CCSD

International audience. Introduction:The neuron-specific K-Cl cotransporter KCC2 maintains low intracellular chloride levels, which are crucial for fast GABAergic and glycinergic neurotransmission. KCC2 also plays a...

The Kainate Receptor Subunit GluK2 Interacts With KCC2 to Promote Maturation of Dendritic Spines

Archive ouverte | Kesaf, Sebnem | CCSD

International audience. Kainate receptors (KAR) play a crucial role in the plasticity and functional maturation of glutamatergic synapses. However, how they regulate structural plasticity of dendritic spines is not ...

Protective Role of Low Ethanol Administration Following Ischemic Stroke via Recovery of KCC2 and p75NTR Expression

Archive ouverte | Khirug, Stanislav | CCSD

International audience. A striking result from epidemiological studies show a correlation between low alcohol intake and lower incidence for ischemic stroke and severity of derived brain injury. Although reduced apo...

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