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Characterization of Atmospheric Pressure Multijet Plasma Source Effects on Mouse Skin
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International audience. Over the past decade, there has been a growing interest in the development of cold atmosphericpressure plasmas for new biomedical applications. This so called Plasma Medicine concernsvarious clinical indications, including infectious diseases and recently, cancer treatment [1].Besides encouraging demonstrations, it has been shown that tolerance and safety issues should beconsidered with great care for any therapeutic application [2]. A new generation of applicators,able to generate multiple jets from a single primary plasma jet, has been developed and qualifiedthrough in vitro experiments. Moreover, they have shown multiple interests (cf. the presentation ofTh. Maho and colleagues in this conference).Using one of these multijet plasma sources, we have proceeded to in vivo treatments on healthymice skin. Various assays have been carried, on nude mice (hairless mice) and CBl57/6 mice (hairymice), which skins have different properties. The distance between the nozzle and the skin surfaceof the treated mouse can be adjusted by applying a spacer (in order to guarantee a constant gapduring treatment - spacer not shown). The presence or absence of skin damages caused by theplasma was assessed as a function of time, distance and delivered power.Fig. 1: Assays of multijet plasma source from single Plasma Gunon Nude mouse (left) and CBl57/6 mouse (right)Between the applicator and the target, plasma jets could appear either clearly separated from eachother or as a more diffuse discharge. Depending on the distance set between the nozzle and thetissue, different thermal effects and skin damages have been observed. The experimental resultsobtained from the characterization of these variables and their effects on the healthy mouse skinsurface will be presented. These promising results will be used as guidance for the application ofmultijet plasma on decontamination procedures (cf. the presentation of Th. Maho et al.).AcknowledgementsThis work was supported by the CNRS PEPS project ACUMULTIPLAS and the ITMO Cancer inthe frame of the Plan Cancer, project N°17CP086-00.References[1] M. Vandamme et al, Plasma Medicine 1(1): 27-43 (2011)[2] S. Kos et al, PLoS ONE 12(4), e0174966 (2017)
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