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Rescuing cardiac automaticity in L-type Cav1.3 channelopathies and beyond

Archive ouverte | Mesirca, Pietro | CCSD

International audience. Pacemaker activity of the sino-atrial node generates the heart rate. Disease of the sinus node and impairment of atrioventricular conduction induce an excessively low ventricular rate (bradyc...

Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity

Archive ouverte | Torrente, Angelo | CCSD

Une correction portant sur la figure 1b a été publiée sous le DOI 10.1007/s00424-020-02431-z.. International audience. The heart automaticity is a fundamental physiological function in vertebrates. The cardiac impul...

Cholinergic regulation of cardiac pacemaker activity by l-type cav1.3 channels

Archive ouverte | Talssi, Leïla | CCSD

International audience. Introduction : The cholinergic regulation of heart rate (HR) is mediated by acetylcholine (ACh)-dependent activation of M2-receptors (M2R). Activated M2R promote release of the βγ-subunit of ...

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