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Global genome decompaction leads to stochastic activation of gene expression as a first step toward fate commitment in human hematopoietic cells

Archive ouverte | Parmentier, Romuald | CCSD

International audience. When human cord blood–derived CD34+ cells are induced to differentiate, they undergo rapid and dynamic morphological and molecular transformations that are critical for fate commitment. In pa...

Differentiation is accompanied by a progressive loss in transcriptional memory

Archive ouverte | Fourneaux, Camille | CCSD

International audience. Abstract Background Cell differentiation requires the integration of two opposite processes, a stabilizing cellular memory, especially at the transcriptional scale, and a burst of gene expres...

An image-guided microfluidic system for single-cell lineage tracking

Archive ouverte | Aslan Kamil, Mahmut | CCSD

International audience. Cell lineage tracking is a long-standing and unresolved problem in biology. Microfluidic technologies have the potential to address this problem, by virtue of their ability to manipulate and ...

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