Synergistic effects of citrulline supplementation and exercise on performance in male rats: evidence for implication of protein and energy metabolisms

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Goron, Arthur | Lamarche, Frédéric | Cunin, Valérie | Dubouchaud, Herve | Hourdé, Christophe | Noirez, Philippe | Corne, Christelle | Couturier, Karine | Seve, Michel | Fontaine, Eric, M. | Moinard, Christophe

Edité par CCSD ; Portland Press -

International audience. Background: Exercise and citrulline (CIT) are both regulators of muscle protein metabolism. However, the combination of both has been under-studied yet may have synergistic effects on muscle metabolism and performance. Methods: Three-month-old healthy male rats were randomly assigned to be fed ad libitum for 4 weeks with either a citrulline-enriched diet (1 g·kg-1·day-1) (CIT) or an isonitrogenous standard diet (by addition of nonessential amino acid) (Ctrl) and trained (running on treadmill 5 days·week-1) (ex) or not. Maximal endurance activity and body composition were assessed, and muscle protein metabolism (protein synthesis, proteomic approach) and energy metabolism [energy expenditure, mitochondrial metabolism] were explored.

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