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The DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of ROS

Archive ouverte | Niocel, Mathilde | CCSD

International audience. Human apolipoprotein B mRNA-editing catalytic polypeptide-like 3 proteins (APOBEC3s or A3s) are cytosine deaminases that protect cells by introducing promutagenic uraciles in invading retro-e...

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Archive ouverte | Cordeil, Stéphanie | CCSD

International audience. Type I interferons induce a complex transcriptional program that leads to a generalized antiviral response against a large panel of viruses, including human immunodeficiency virus type 1 (HIV...

The susceptibility of primate lentiviruses to nucleosides and Vpx during infection of dendritic cells is regulated by CA

Archive ouverte | Barateau, Véronique | CCSD

International audience. The block toward human immunodeficiency virus type 1 (HIV-1) infection of dendritic cells (DCs) can be relieved by Vpx (viral protein X), which degrades sterile alpha motif-hydroxylase domain...

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