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Absence of a High Level of Duplication of the Plasmepsin Gene in Africa

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Robert, Marie Gladys | Tsombeng, Francis Foguim | Gendrot, Mathieu | Mosnier, Joel | Amalvict, Remy | Benoit, Nicolas | Torrentino-Madamet, Marylin | Pradines, Bruno | Imported, French Natl Reference Ctr

Edité par CCSD ; American Society for Microbiology -

International audience. Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low prevalence of piperaquine reduced susceptibility in Africa. Additionally, the few isolates with reduced susceptibility to piperaquine did not harbor amplification of the plasmepsin II gene.

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