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The anti-IgE mAb Omalizumab induces adverse reactions by engaging Fcγ receptors

Archive ouverte | Balbino, Bianca | CCSD

International audience. Omalizumab is an anti-IgE monoclonal antibody (mAb) approved for the treatment of severe asthma and chronic spontaneous urticaria. Use of Omalizumab is associated with reported side effects, ...

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome

Archive ouverte | Stackowicz, Julien | CCSD

International audience. Gain-of-function mutations in NLRP3 are responsible for a spectrum of autoinflammatory diseases collectively referred to as “cryopyrin-associated periodic syndromes” (CAPS). Treatment of CAPS...

Conditional neutrophil depletion challenges their contribution to mouse models of anaphylaxis

Archive ouverte | Stackowicz, Julien | CCSD

International audience. No abstract available

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