Norine, Florine, s2m : powerful bioinformatics resource and tools for the discovery of novel nonribosomal peptides, natural metabolites with versatile activities

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Esmaeel, Qassim | Dufresne, Yoann | Flissi, Areski | Pupin, Maude | Jacques, Philippe | Leclère, Valérie

Edité par CCSD -

International audience. NonRibosomal peptides (NRPs) are a huge untapped resource of natural products displaying activities with applications in health (i.e. antibiotics) or in biocontrol (especially siderophores and lipopeptides with antifungal activity). NRPs are microbial secondary metabolites produced by enzymatic complexes, so-called non-ribosomal peptide synthetases (NRPSs). These modular assembly lines work step by step to build the peptides, each module adding one monomer to the peptidic chain. Considering the modular organization of NRPSs, and the structural specific features of the NRPs, dedicated bioinformatics tools have been developed with the aim of accelerating the screening for new active metabolites.

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