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A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner

Archive ouverte | Gowravaram, Manjeera | CCSD

International audience. The RNA helicase UPF1 is a key component of the nonsense mediated mRNA decay (NMD) pathway. Previous X-ray crystal structures of UPF1 elucidated the molecular mechanisms of its catalytic acti...

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Archive ouverte | Hodeib, Samar | CCSD

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Nonsense‐mediated mRNA decay involves two distinct Upf1‐bound complexes

Archive ouverte | Dehecq, Marine | CCSD

International audience. Nonsense-mediated mRNA decay (NMD) is a translation-dependent RNA degradation pathway involved in many cellular pathways and crucial for telomere maintenance and embryo development. Core NMD ...

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