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Tropheryma whipplei Increases Expression of Human Leukocyte Antigen-G on Monocytes to Reduce Tumor Necrosis Factor and Promote Bacterial Replication

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Azzouz, Eya Ben | Boumaza, Asma | Mezouar, Soraya | Bardou, Matthieu | Carlini, Federico | Picard, Christophe | Raoult, Didier | Mege, Jean-Louis | Desnues, Benoit

Edité par CCSD ; Elsevier -

International audience. Infection with Tropheryma whipplei has a range of effects-some patients can be chronic carriers without developing any symptoms whereas others can develop systemic Whipple disease, characterized by a lack a protective inflammatory immune response. Alterations in major histocompatibility complex, class I, G (HLA-G) function have been associated with several diseases. We investigated the role of HLA-G during T whipplei infection.

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